ZAP-70 Expression in B-Cell Hematologic Malignancy Is Not Limited to CLL/SLL
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چکیده
منابع مشابه
ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL.
ZAP-70 is a tyrosine kinase expressed in normal T cells and NK cells. Expression of ZAP-70 has been associated with poor prognosis in B-cell chronic lymphocytic leukemia and might be a surrogate marker for immunoglobin heavy chain (IGH) mutational status in that disease. Little is known about ZAP-70 expression in other hematologic malignant neoplasms. We examined 446 specimens representing a ra...
متن کاملExpression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.
We examined isolated leukemia B cells of patients with chronic lymphocytic leukemia (CLL) for expression of zeta-associated protein 70 (ZAP-70). CLL B cells that have nonmutated immunoglobulin variable region genes (V genes) expressed levels of ZAP-70 protein that were comparable to those expressed by normal blood T cells. In contrast, CLL B cells that had mutated immunoglobulin variable V gene...
متن کاملZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia.
BACKGROUND AND OBJECTIVES ZAP-70 expression is a recognized prognostic marker in chronic lymphocytic leukemia (CLL). The aim of this study was to analyze whether the methylation status of the ZAP-70 gene is associated with expression of the ZAP-70 protein. DESIGN AND METHODS Patients with CLL (n=87), acute lymphoblastic leukemia (n=13), mantle cell leukemia (n=13) and splenic marginal zone ly...
متن کاملClinical Significance of ZAP-70 Protein Expression in B-cell Chronic Lymphocytic Leukemia Short title: ZAP-70 and prognosis in B-CLL
Prepublished online April 6, 2006; Amadori Gattei, Paolo de Fabritiis, Maria Cantonetti, Francesco Lo Coco, Domenico Del Principe and Sergio Ottaviani, Paola Panetta, Antonio Bruno, Riccardo Bomben, Giovanna Suppo, Massimo Degan, Valter Licia Antonella Zucchetto, Rita Marini, Pasquale Niscola, Maria Antonietta Irno Consalvo, Carla Mazzone, Maria Ilaria Del Principe, Giovanni Del Poeta, Francesc...
متن کاملThe clinical significance of ZAP-70 and CD38 expression in B-cell chronic lymphocytic leukaemia.
BACKGROUND B-cell chronic lymphocytic leukaemia (B-CLL) is a disease with a highly variable clinical course; some patients never need treatment, while others require intensive treatment early after diagnosis. Recently, some new prognostic factors, such as IgVH mutational status, ZAP-70 and the expression of CD38 in leukaemic cells were introduced to identify attenuated versus progressive types ...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173,1943-7722
DOI: 10.1309/wvqpvdf8uf7av21x